汤静.RAAS基因多态与男性原发性高血压患者不同强度有氧运动降压效果的关系[J].北京体育大学学报,2017,40(5):46-50+58.
RAAS基因多态与男性原发性高血压患者不同强度有氧运动降压效果的关系
Association of RAAS Gene Polymorphisms and Effects of Different Intensity Aerobic Exercise on Blood Pressure in Men with Essential Hypertension
投稿时间:2016-05-05  
DOI:10.19582/j.cnki.11-3785/g8.2017.05.008
中文关键词:  关键词:肾素-血管紧张素-醛固酮系统  基因多态  原发性高血压  有氧运动  血压
英文关键词:Keywords: renin-angiotensin-aldosterone system  gene polymorphism  essential hypertension  aerobic exercise  blood pressure
基金项目:基金项目:河南省重点科技攻关项目(编号:162102310082)。
作者单位
汤静 河南工程学院体育部河南 郑州 451191 
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中文摘要:
      摘要:目的:探讨肾素-血管紧张素-醛固酮系统(RAAS)基因多态与男性原发性高血压患者不同强度有氧运动降压效果的关系,为制定个性化运动处方提供依据。方法:78名男性原发性高血压患者利用聚合酶链式反应(PCR)测定血管紧张素转化酶(ACE)基因I/D、血管紧张素II 1型受体(AT1R)基因A/C和醛固酮合酶(CYP11B2)基因T/C多态。所有受试者分别以60%VO2max进行一次中等强度有氧运动实验(MAET)、以40%VO2max进行一次低强度有氧运动实验(LAET)以及1次安静对照实验(RCT),时间均为40 min。每次实验前后测定24 h动态血压(ABP),包括收缩压(SBP)和舒张压(DBP)。结果:各基因型分布频率均符合哈-温遗传平衡定律(P>0.05)。与实验前比较,MAET、LAET后各基因型组血压水平均显著性下降(P<0.05),RCT后则无显著性变化(P>0.05);LAET后,ACE-DD基因型组SBP低于ACE-II/ID基因型组(P<0.05)。LAET后,≥3个RAAS高危等位基因组SBP和DBP均低于≤2个高危等位基因组(P<0.05);MAET和RCT后,两组血压水平均无显著性差异(P>0.05)。结论:RAAS基因多态可影响急性有氧运动的降压效应。ACE-DD基因型携带者低强度有氧运动的降压效果优于ACE-I等位基因(II/ID)者;≥3个RAAS高危等位基因患者低强度有氧运动的降压效果优于≤2个等位基因变异者;中等强度运动以及安静对照实验后,血压无显著性改变。
英文摘要:
      Abstract: Objective: This study aimed at exploring the association of renin-angiotensin-aldosterone system (RAAS) gene polymorphisms and effects of different intensity aerobic exercise on blood pressure in men with essential hypertension, and providing evidence for individual exercise prescription for hypertensive patients. Methods: The Angiotensin converting enzyme (ACE) gene I/D, angiotensin II type1 receptor (AT1R) gene A/C and aldosterone synthase gene (CYP11B2) T/C polymorphisms of seventy-eight men with essential hypertension were tested by polymerase chain reaction (PCR). All patients performed three 40 min tests including a moderate-intensity aerobic exercise test with 60%VO2max (MAET), a low-intensity aerobic exercise test with 40%VO2max (LAET) and a resting control test (RCT). Ambulary blood pressure (ABP) including systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured before and after each trial. Results: The distribution frequency of all genotypes was coincident with Hardy-Weinberg equilibrium (P > 0.05). Compare with pre-test, blood pressure of all genotype groups was reduced (P < 0.05) after MAET and LAET, and no change after RCT (P > 0.05); after LAET, SBP of ACE-DD genotype group was lower than that of ACE-II/ID group (P < 0.05). After LAET, SBP and DBP in subjects with ≥3 variant RAAS polymorphisms were lower than those with ≤2 variant alleles; after MAET and RCT, there was no significant difference between two groups (P > 0.05). Conclusions: RAAS polymorphisms may interact with acute aerobic exercise induced blood pressure reduction. The effect of low intensity aerobic exercise reduced blood pressure in ACE-DD genotype carriers is better than that in ACE-I allele (II/ID); the effect of low intensity aerobic exercise reduced blood pressure in subjects with multiple (≥3) variant RAAS polymorphisms is better than that with fewer variant alleles (≤2); there was no significant difference of blood pressure after moderate-intensity aerobic exercise and resting control test.
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