赵丽,李岩.2015年“第62届美国运动医学会年会”专栏:体力活动与AD高危人群认知功能[J].北京体育大学学报,2015,38(8):50-57.
2015年“第62届美国运动医学会年会”专栏:体力活动与AD高危人群认知功能
Physical Activity and Cognitive Function in Older Adults at Increased Risk for Alzheimer’s Disease
投稿时间:2015-08-05  
DOI:
中文关键词:  关键词:阿尔茨海默病  认知  运动  体力活动  载脂蛋白E基因表型  遗传风险  轻度认知障碍
英文关键词:Keywords: Alzheimer’s disease  cognition  exercise  physical activity  APOE genotype  genetic risk  mild cognitive impairment
基金项目:基金项目:国家自然科学基金资助项目(No.31271278);国家科技支撑计划课题资助项目(No. 2012BAK21B03);中央高校基本科研业务费专项资金资助项目(No.2015JX002)。
作者单位
赵丽 北京体育大学 北京 100084 
李岩 北京体育大学 北京 100084 
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中文摘要:
      摘要:2015年ACSM第62届年会EIM专题关于全球人口老龄化的问题,在进一步肯定了积极参与体力活动或规律运动锻炼对健康老年人的认知功能具有促进作用的基础上,提出当存在AD高风险因素诸如APOE-ε4等位基因携带者、已确诊为轻度认知障碍(MCI)或者患有代谢性疾病时,体力活动对于该人群认知功能的影响就更为重要。本文将对近年来关于体力活动或运动锻炼干预对具有罹患AD高危因素人群其认知功能的差异影响、临床表现及大脑结构功能影响做一综述。已有研究结果提示对未来罹患痴呆症具有高遗传性风险因素的人群,运动干预的保护作用较大。运动训练可以有效地稳定MCI患者认知功能,提高AD早期患者心肺适能可以增加其脑容量。APOE-ε4等位基因携带者高强度体力活动可以减少其脑内淀粉样蛋白沉积、激活相关神经回路。随着对运动干预认识深入,在具有罹患AD的高危人群中,开展运动干预的随机临床试验、行为学检测及神经影像学的变化特征研究将是未来的研究重点。
英文摘要:
      Abstract: Physical activity (PA) and exercise training are again confirmed to help maintain cognitive function in healthy older adults at aging symposium in the 62nd ACSM annual meeting, and they are especially important for cognitive function or brain function in those at increased risk for Alzheimer’s disease through the presence of the apolipoproteinE epsilon4 (APOE-ε4) allele, diagnosis of mild cognitive impairment (MCI), or the presence of metabolic disease. Here, we examine the question of whether PA and exercise interventions may differentially impact cognitive trajectory, clinical outcomes, and brain structure and function among individuals at the greatest risk for AD. The literature suggests that the protective effects of PA on risk for future dementia appear to be larger in those at increased genetic risk for AD. Exercise training is also effective at helping to promote stable cognitive function in MCI patients, and better cardiorespiratory fitness is associated with bigger brain volume in early-stage AD patients. In APOE-ε4 allele carriers, greater level of PA may be more effective in reducing amyloid burden and is associated with greater activation of memory-related neural circuits. A greater research emphasis should be placed on randomized clinical trials for exercise, with clinical, behavioral, and neuroimaging outcomes in people at increased risk for AD.
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