胡柏平,苏铁柱.游泳运动对攻击行为大鼠海马5-HT1A-R、5-HT1B-R的影响[J].北京体育大学学报,2015,38(1):68-73.
游泳运动对攻击行为大鼠海马5-HT1A-R、5-HT1B-R的影响
Effect of Swimming on Hippocampus 5-HT1A-R and 5-HT1B-R in Rats with Aggressive Behavior
投稿时间:2014-03-20  
DOI:10.19582/j.cnki.11-3785/g8.2015.01.011
中文关键词:  关键词:游泳  大鼠  攻击行为  海马  5-HT1A-R  5-HT1B-R
英文关键词:Key words: swimming  rats  aggressive behavior  hippocampus  5-HT1A-R  5-HT1B-R
基金项目:陕西师范大学“211工程”学科建设项目(2014)。
作者单位
胡柏平 陕西师范大学体育学院陕西 西安 710062 
苏铁柱 商洛学院陕西 商洛 726000 
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中文摘要:
      摘要:目的:探讨游泳运动对攻击行为大鼠海马神经元5-HT1A-R、5-HT1B-R蛋白水平的表达变化,为运动改善大鼠攻击行为发生机制的阐明提供实验依据。方法:成年健康雄性SD大鼠36只,适应1周后随机分为:安静对照组、攻击模型组、攻击模型游泳组、入侵组。通过旷场实验检测大鼠的行为活动,采用Western-blot法及免疫组织化学法检测大鼠海马神经元5-HT1A受体、5-HT1B受体蛋白表达变化。结果:攻击模型建立成功后大鼠的总路程、平均速度、中央活动时间均较高,经过8周游泳运动干预后攻击模型大鼠的总路程、平均速度、中央活动时间均下降P<0.05;攻击模型组大鼠海马神经元5-HT1A受体、5-HT1B受体蛋白表达明显下降(P<0.05),经过8周游泳运动干预后大鼠海马5-HT1A受体、5-HT1B受体蛋白表达明显升高(P<0.05)。结论:游泳运动对攻击模型大鼠攻击行为具有改善作用,其作用机制可能与海马神经元5-HT1A受体、5-HT1B受体表达增强,使5-HT能系统功能提高,从而增强了中枢神经抑制作用有关。
英文摘要:
      Abstract: Objective: The purpose of this study was to test the effect of swimming on hippocampus neurons 5-HT1A-R and 5-HT1B-R protein levels in rats with aggressive behavior, for providing references to explain the mechanism of exercise alleviating aggressive behavior. Methods: Thirty-six SD male rats were divided into following four groups after one-week adapted training, groups are: control group (C), aggressive behavior group (A), aggressive behavior and swimming group (AS), and invasion group (I). Rats’ activity was tested by field experiment, hippocampus neurons 5-HT1A-R and 5-HT1B-R protein levels were measured by Western blotting and Immunohistochemistry. Results: The total distance, mean speed and central activity time in A group were higher than those in C group, but they were decreased in AS group (P < 0.05) compared to A group. 5-HT1A-R and 5-HT1B-R protein levels were lower in A group than those in C group (P < 0.05), but they were increased in AS group compared to A group (P < 0.05). Conclusion: Swimming can alleviate rats’ aggressive behavior that is related to the increase of 5-HT1A-R and 5-HT1B-R after swimming that improves 5-HT system and enhances the inhibition effect of central nervous.
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