周文婷,胡扬.我国优秀长跑运动员TSHR基因多态性分析[J].北京体育大学学报,2012,35(12):49-52.
我国优秀长跑运动员TSHR基因多态性分析
The Polymorphisms of the TSHR Gene in Elite National Long-distance Runner
投稿时间:2012-08-17  
DOI:
中文关键词:  关键词:TSHR  基因多态性  有氧耐力  遗传标记  长跑运动员
英文关键词:Key words: TSHR  polymorphisms  aerobic endurance performance  genetic mark  long-distance runner
基金项目:基金项目:国家自然科学基金(项目批准号:31071032)。通信作者:胡扬。
作者单位
周文婷 哈尔滨体育学院运动人体科学系黑龙江 哈尔滨 150001 
胡扬 北京体育大学北京 100084 
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中文摘要:
      摘要:目的:研究我国优秀长跑运动员促甲状腺激素受体(thyrotropinreceptor,TSHR)基因多态性分布特征,寻找与有氧耐力表型相关的遗传学分子标记。方法:应用基质辅助激光解吸附电离飞行时间质谱检测技术,对123名中国北方汉族优秀长跑运动员与127名中国北方汉族普通大学生TSHR基因的SNP/Glu727Asp和SNP/Pro52Thr位点进行解析并分析比较。结果:运动员组在Glu727Asp及Pro52Thr位点的基因型和等位基因频率与对照组相比均无显著性差异(P>0.05)。结论:TSHR基因的Glu727Asp和Pro52Thr位点与有氧耐力不相关。
英文摘要:
      Abstract: Objectives: To study the single nucleotide polymorphisms (SNPs)in the thyrotropin receptor (TSHR) gene in the Chinese elite national long-distance runner and to explore the genetic marks associated with aerobic endurance performance. Methods:Three SNPs (SNP/Glu727Asp and SNP/Pro52Thr) in TSHR gene regions were selected. The genotypes of the 123 elite long-distance runner and 127 college students from northern China were analyzed using the matrix assisted laser desorption ionisation-time of flight mass spectrometry method(MALDI-TOF). Results:No significant differences of the genotype and allele frequencies of Glu727Asp and Pro52Thr loci in TSHR gene were found between the elite athletes and the controls (P>0.05). Conclusion: SNP/Glu727Asp and SNP/Pro52Thr were not associated with aerobic endurance of Chinese elite endurance athletes.
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