石丽君,李珊珊,熊开宇,龚丽景,等.有氧运动对大鼠心血管和胸主动脉平滑肌的功能重塑作用[J].北京体育大学学报,2011,34(11):47-50.
有氧运动对大鼠心血管和胸主动脉平滑肌的功能重塑作用
Functional Remodeling of the Aerobic Exercise on the Cardiovascular System and Thoracic Aortic Smooth Muscle of Rats
投稿时间:2011-08-30  
DOI:
中文关键词:  关键词:有氧运动  功能重塑  胸主动脉  平滑肌
英文关键词:Key words: aerobic exercise  functional remodeling  thoracic aorta  smooth muscle
基金项目:国家自然科学基金项目“有氧运动诱导衰老血管功能重塑的通道机制”(31071033);北京市优秀人才培养资助“BKCa在有氧运动诱导衰老血管平滑肌功能重塑中的作用”(2010D009010000001);国家人力资源和社会保障部留学科技活动项目择优资助。
作者单位
石丽君 北京体育大学北京100084 
李珊珊 北京体育大学北京100084 
熊开宇 北京体育大学北京100084 
龚丽景 北京体育大学北京100084 
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中文摘要:
      摘 要:目的:探讨有氧运动对大鼠心血管和胸主动脉平滑肌的功能重塑作用及可能的钾通道机制。方法:选用2月龄雄性Wistar大鼠20只,随机分为安静对照组和有氧运动组,进行8周跑台运动。8周后,选取部分动物(各组5只)进行股动静脉插管,插管留置体内并从颈部皮肤切口穿出固定。术后恢复1 d后,于在体、清醒状态下测定基础血压、心率,并经股静脉注射Ang II和非特异性钾通道阻断剂TEA,观察其心血管反应。另10只大鼠,开胸取胸主动脉,去内皮,并制备血管环,进行离体血管收缩特性检测。结果:1)有氧运动后大鼠的安静心率显著下降;平均动脉压有下降趋势,但与安静对照组比无显著性差异;2)静脉注射Ang II引起的升压反应幅度减小;3)静脉注射非特异性钾通道阻断剂TEA可诱发升压反应,且运动组较安静对照组显著;4)两组去内皮胸主动脉血管环对于Ang II(10-9~10-4M)均有浓度依赖性收缩,但有氧运动组的最大张力显著低于安静对照组;5)TEA(5×10-3M)可诱发大鼠血管张力增加,运动组升高幅度显著大于安静组。结论:有氧运动可诱导大鼠心血管和胸主动脉平滑肌出现功能重塑,其中钾通道活性的增强可能是重要机制之一。
英文摘要:
      Abstract:Objective: To investigate the aerobic exercise-induced functional remodeling of the rat cardiovascular systmem and thoracic aortic smooth muscle,and to explore the possible potassium channel mechanisms underlying these effects. Methods: 20 male Wistar rats (2M) were randomly divided into sedentary group and exercise group. Training protocol: 8 week treadmill. After 8 weeks,some animals (n=5 in each group) underwent femoral arterial and venous cannulation. Catheters were tunneled subcutaneously,exteriorized at the nape of the neck. Following one day recovery,the basal blood pressure,heart rate and the cardiovascular responses to intravenous (i. v. ) injection of Ang II and non-specific K+ channel blocker TEA were monitored in vivo. In the other 10 animals,the thoracic aorta was carefully exposed after thoracotomy and dissected free. Segments were cut into rings and the endothelial cell lining was removed. The vessel contractility was examined in vitro. Results:1) After the aerobic exercises,the heart rate at rest reduced significantly. The mean arterial pressure of rats had a tendency to decrease but there was no significant difference between the sedentary and the exercise groups at rest. 2)The pressor responses induced by i. v. injection of Ang II were attenuated in the exercise group compared with that in the sedentary group;3) The pressor responses induced by i. v. injection of TEA,was significantly enhanced after exercise training;4)Ang II (10-9~10-4M) caused a significantly increase of vascular tone in a concentration-dependent manner in both groups,while the increase amplitude was less in exercise group than in the sedentary group;5) TEA (5×10-3 M) could induce an increase of vessel contractility in two groups,while the amplitude of increase was significantly enhanced after exercise training. Conclusion: Aerobic exercise training can induce functional remodeling of the rat cardiovascular system and thoracic aorta smooth muscle,in which the enhancement of the potassium channel activity is a very possible mechanism.
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